Since 1991, the Embassy of Italy has its headquarters in El Rosal district of the Chacao Municipality, which concentrates the main business and commercial activities of the capital and most of the headquarters accredited to the Bolivarian Republic of Venezuela

The Embassy occupies the top two floors of a modern building that is also home to the stock exchange and the Chacao Municipality.

The Embassy hosts the headquarters of ICE (Istituto per il Commercio Estero), the Agency for Overseas Promotion and Internationalization of Italian Companies.